Grant from the Aligning Science Across Parkinson’s (ASAP) initiative

Per Svenningsson has been awarded a grant of approximately 1.86 million US dollar for three years, from the Aligning Science Across Parkinson’s (ASAP) initiative for an ambitious, multidisciplinary effort to study how abnormal protein aggregates may spread from the gut to the brain to drive the early stages of Parkinson’s disease. The total award is 8.9 million US dollar grant for three years.

Our research on how ketamine prevents depression was published on Molecular Psychiatry

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The discovery that the anaesthetic ketamine can help people with severe depression has raised hopes of finding new treatment options for the disease. Researchers at Karolinska Institutet have now identified novel mechanistic insights how the drug exerts its antidepressant effect. The findings have been published in the journal Molecular Psychiatry.

Article published in Molecular Psychiatry

Ji-Seon Seo et al. found that p11 is highly expressed in ependymal cells, and is significantly decreased in patients with MDD, and in two mouse models of depression induced by chronic stress. These results identify a new role and a key molecular determinant for ependymal cell-driven CSF flow in mood disorders.

Link to article