Selected publications:
Per Svenningsson, Per Odin, Filip Bergquist, Karin Wirdefeldt, Dag Nyholm, Mattias Andréasson, Ioanna Markaki, Anders C Johansson, Måns Jergil, Christopher Jankosky, Mark A Varney, Fabienne Herbrecht, Steven A Johnson, Adrian Newman-Tancredi. NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy. Mov Disord 40, 1134-1142 (2025). doi: 10.1002/mds.30175.
Anderson Camargo, Anna Nilsson, Reza Shariatgorji, Ellen Appleton, Niclas Branzell, Daniel Doyon, Mattia Giovenzana, Xiaoqun Zhang, Daniel Dautan, Per E. Andren & Per Svenningsson. Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior. Mol Psychiatry 30, 2504–2516 (2025). doi.org/10.1038/s41380-024-02853-6.
Alejandro Díaz-Holguín, Marcus Saarinen, Duc Duy Vo, Andrea Sturchio, Niclas Branzell, Israel Cabeza de Vaca, Huabin Hu, Núria Mitjavila-Domènech, Annika Lindqvist, Pawel Baranczewski, Mark J. Millan, Yunting Yang, Jens Carlsson, and Per Svenningsson. AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine–associated receptor 1. Science Advances 10, 32, 2024. doi.org/10.1126/sciadv.adn1524.
Shervin Khosousi, Andrea Sturchio, Ellen Appleton, Wojciech Paslawski, Michael Ta, Michael Nalls, Andrew B Singleton, Hirotaka Iwaki, Per Svenningsson. Increased CSF DOPA Decarboxylase Correlates with Lower DaT-SPECT Binding: Analyses in Biopark and PPMI Cohorts. Mov Disord 39, 1881-1885 (2024). doi.org/10.1002/mds.29835.
Ioannis Mantas, Ivana Flais, Yuvarani Masarapu, Tudor Ionescu, Solène Frapard, Felix Jung, Pierre Le Merre, Marcus Saarinen, Katarina Tiklova, Behzad Yaghmaeian Salmani, Linda Gillberg, Xiaoqun Zhang, Karima Chergui, Marie Carlén, Stefania Giacomello, Bastian Hengerer, Thomas Perlmann & Per Svenningsson. Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice. Nat Commun 15, 8176 (2024). doi.org/10.1038/s41467-024-52429-9.
Yachao He, Ibrahim Kaya, Reza Shariatgorji, Johan Lundkvist, Lars U. Wahlberg, Anna Nilsson, Dejan Mamula, Jan Kehr, Justyna Zareba-Paslawska, Henrik Biverstål, Karima Chergui, Xiaoqun Zhang, Per E. Andren,Per Svenningsson. Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents. Nat Commun 14, 5804 (2023). doi.org/10.1038/s41467-023-41539-5. Mov Disord. 2021 Feb 26. doi: 10.1002/mds.28545.
Wojciech Paslawski, Shervin Khosousi, Ellen Hertz, Ioanna Markaki, Adam Boxer, Per Svenningsson. Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson’s disease. Transl Neurodegener 12, 42 (2023). doi: 10.1186/s40035-023-00374-w.
Mantas I, Vallianatou T, Yang Y, Shariatgorji M, Kalomoiri M, Fridjonsdottir E, Millan MJ, Zhang X, Andrén PE, Svenningsson P. TAAR1 dependent and independent actions of tyramine in interaction with glutamate underlie central effects of monoamine oxidase inhibition. Biological Psychiatry (2020). https://doi.org/10.1016/j.biopsych.2020.12.008.
Paslawski W, Zareba-Paslawska J, Zhang X, Hölzl K, Wadensten H, Shariatgorji M, Janelidze S, Hansson O, Forsgren L, Andrén PE, Svenningsson P. α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson’s disease patients. Proc Natl Acad Sci U S A. (2019) Jul 23;116(30):15226-15235.
Green H, Zhang X, Tiklova K, Volakakis N, Brodin L, Berg L, Greengard P, Perlmann T, Svenningsson P. Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease. Proc Natl Acad Sci U S A. (2017) Mar 7;114(10):2735-2740.
Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science. (2006) Jan 6;311(5757):77-80.